Convenient Multicomponent One‐Pot Synthesis of 2‐Iminothiazolines and 2‐Aminothiazoles Using Elemental Sulfur Under Aqueous Conditions

Herein, we present a novel one-pot aqueous reaction for the synthesis of 2-iminothiazolines and 2-aminothiazoles using isocyanides, amines, sulfur, 2′-bromoacetophenones. The three-component preparation thioureas is followed by cyclization leading to heterocyclic product. This efficient mild procedure features excellent step- atom-economy enables chromatography-free diversely substituted 2-iminothiazoline 2-aminothiazole derivatives.